4.005 won't run on Vista Business - Microstudio 4.006 fixes problem

[ddouglass]

When you ran the Windows Update, did you use the Auto Update or the Express Update from their website?
If so you need to run the Custom Update to get other updates that Microsoft does not consider as critical.
The other thing I can think of right now is to look at the Microstudio folder with Windows Explorer. At the top of the window you will see a button labeled Compatability Files. You need to turn this on.
Last I would say try uninstalling it, restart the computer, then re-install and restart it again. It may just be that a component of it didn't install correctly.