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I have used Vogone to reduce or remove a lead instrument as well as vocals.
Bear in mind neither vocal removel or instrument removal is a 100% thing 100% of the time. It all depends on the recording. The least effective are mono tracks and older mono stereo remastered tracks.
The most effective are stereo tracks where the lead was recorded center panned with little or no digitally added reverb.
MTU's newer Vogone is enjoying a degree of success with non-center panned material.
Others may have had different results, but that's been my experience.
Vogone will handle instruments as well as vocals.
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