Read and DO all the changes to your system in this FAQ page:
http://www.mtu.com/faq-test.php?article=98
Admin, I have done every change that you suggested and I still have the lyric sync problem in 4.05. All of the other problems went away. I run Vista and found the aero problem by accident a long time ago and have not run that since. I disabled sidebar also. I have all updates of my drivers. I don't have any problems with 4.03 and will continue to run it until 4.10 release. I absolutly LOVE this Program. It is hard sometime to keep up with all of the 'fixes' in the forum. Sometimes the Post gets off track and take a differant direction. I'll hang in there and continue to blame VISTA when things go wrong at shows (last 2 weeks error free). Keep up the good work. 
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Show Computer (Custom Built)
OS Windows XP SP3
Processor 2.7GHz single core
Motherboard with 6 channel Audio
2GB RAM
250GB AV hard drive
256MB Video Card with S-video and dual display
DVD-ROM Drive
430watt power supply
Rack mountable case
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