Just got through digging into my Norton Ghost manual, and
Norton Ghost does support USB imaging and cloning. It will create a disaster boot disk which can be used for either mode. Never bothered before as I don't use a USB drive. To top it off, I'm using a five year old version(2003)
Guess "this other guy" wasn't familiar with Norton Ghost.(no insult intended, heck I've been using Norton for five years and never knew it was USB compatable

)
So, Bryant, I'd say Yes to your question if you used Norton Ghost and created a disaster recovery disc. For any other program, read your manual.