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billyo,
I too use mackie. CFX12 mixer, 450's and 1501 sub. What you are describing may be a ground loop problem coming off the computer. When I first started using Hoster over three yaers ago I encounterd an awful hum. I thought it was the board, the speaker. I didn't know. What it ended up being is I had to use a three to two ground plug on my computer cord. Try that and see if it helps.
Kelly
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