Since V5.3 now checks and prevents running over 2GB, and with Partition Magic software creating a "valid" logical drive greater than 2Gb, some of these concerns may not be as important today.
When talking about solutions or use, it would help us all if everyone adds what version of Microeditor they have been running. That way we can know if this is "ancient" or "current" recommendations. We added the 400 file limit to overcome ancient problems, as Armin was asking about at the start of this thread.
It there are performance problems with V5.3, we would like to know this.